by William Clearfield, D.O. for Longevinex

Prelude: Where’s Teddy?

Those who revel in Teddy’s stories (1-2) might be slightly disappointed today. An enthusiastic student of all things anti-aging, Teddy volunteered as a research assistant. An opportunity arose that perfectly matched his skill set. Teddy is on assignment to find the perfect anti-aging and anti-inflammatory supplement. What follows is his report. Teddy will be back in person shortly.


Worth USD 40.49 billion in 2020, the global market for anti-aging and anti-inflammatory products continues to grow at an annual rate of 5.4%. (3) Our conundrum lies in that many over-the-counter products advertise dramatic results backed by relatively little scientific data to support their claims.

A quick Google search for “anti-aging” products yields 206 million hits in less than one second. A second Google Scholar, the ”search engine” for scholarly literature, results in more than five thousand entries. (4)

As the pursuit of longevity and vibrant health continues to gain prominence, individuals and corporate entities promoting, for example, ‘age-defying, revitalizing, rejuvenating and restoring, and recapture your youth” products are becoming increasingly bold in their pronouncements. As the market crowds, voices of reason, all too often absent in the pursuit of market share, become increasingly extreme.

Teddy’s assignment was to answer the question, if even possible, within a reasonable degree of medical certainty, what constitutes the ideal anti-aging, anti-inflammatory product? Can we construct such a substance? Are there any supplements on the market presently that fit the bill, or do we need to create one from scratch?

The Properties of the Ideal Antiaging and Anti-inflammatory Supplement

My mentor, Dr. Jim Naccarato, starts each lecture with the admonishment to empty our brains of all the “schmutz,” as he describes it.

“Pretend there is a zipper around your forehead. Unzip it, open the top of your skull, turn yourself upside down, and dump the contents. Next, turn upright and rezip. Now that all of the nonsense is out of your system, with a clean slate, we begin.” (5)

Following Dr. Naccarato’s guidelines, we unleashed our inner Teddy to analyze and, if necessary, develop a new “ideal” anti-aging, anti-inflammatory product. Teddy tracked down all of the ingredients that work synergistically to support overall well-being and combat the effects of aging.

Our compound, which we will call Substance X, needs agents to activate antiaging genetic codes and properties to enhance cellular function. It must counter oxidative stress and mitochondrial (energy) dysfunction. Lastly, Substance X should be anti-inflammatory, possess cardiovascular and immune support, be pleomorphic to help regenerate tissue, enhance exercise performance, and show some anti-cancer effects.

With this “shopping list,” Teddy came up with eleven candidates.

“Before I begin,” Teddy wrote, “It is unlikely we will find a single over-the-counter supplement that contains all the listed ingredients. Our “wish” list is quite specific and may vary across different formulations. I expect we will need three, four, or even five supplements to cover my list.”

Was Teddy ever wrong!

The Magnificent Antiaging, Anti-inflammatory Eleven

  1. Trans-resveratrol: (6)
    a.Trans-resveratrol is a highly purified and potent age-defying polyphenol derived from Japanese knotweed. The ideal anti-aging supplement must contain Japanese knotweed-derived trans-resveratrol to ensure a standardized, concentrated product that maximizes resveratrol’s bioavailability and effectiveness.
    b. Unlike nearly all 350 other (cis) resveratrol on the market, trans-resveratrol epigenetically stimulates longevity and drives cellular respiration.
    c. Trans-resveratrol is a potent antioxidant. It protects cells from oxidative stress, supports cardiovascular health, reduces inflammation, resists neoplastic cell changes, and enhances memory, cognition, and bone strength.
    d. We reviewed the ”50 Ways Resveratrol Enhances Our Health” discussed in our last report. (7)
  2. Quercetin: (8)
    a. A versatile antioxidant flavonoid found in fruits and vegetables, quercetin is a potent antioxidant and anti-inflammatory compound.
    b. Quercetin combats oxidative stress while reducing total body inflammation.
    c. Quercetin supports the cardiovascular and immune systems, modulates neoplastic cells, and improves exercise performance by stimulating the production of ATP. ATP runs cellular functions, translating into more precise thought processes, increased energy, and loss of brain “fogginess.”
    d. Quercetin downregulates the production of the transcriptional trigger for inflammation, the notorious NF-κβ gene expression. (9)
  3. Rice Bran IP6:a. In rice bran, IP6, inositol hexaphosphate, is a potent antioxidant and immune function supporter
    IP 6 maintains cellular integrity and supports healthy cell growth. (10)
    c. Rice bran phytate inhibits cholesterol absorption in the gut while lowering LDL (bad) cholesterol on average by 6.91 mg/dL. For every 1 mg/dL drop in LDL, cardiac disease risk decreases by 1-2%.
    d. Rice bran phytate reduces the risk of high-fat diet-induced hyperglycemia. (11-12)
    e. Rice bran phytate is associated with a decreased production of the pro-inflammatory cytokines IL-1B, IL-2, TNF-alpha, and INF-gamma while increasing the production of anti-inflammatory cytokines IL-22 and IL-23. (13)
    f. Rice bran phytate is anti-hypertensive and improves endothelial function. (14-15)
  4. Vitamin D3:
    a. Derived from sunlight, Vitamin D aids in calcium absorption, strengthening bone.
    b. Vitamin D3 reduces inflammation and enhances immune, heart, and blood vessel integrity.
    c. Vitamin D3 regulates insulin production and metabolism. (16)
    d. A “pro-hormone” Vitamin D helps process cortisol and growth hormone. (17)
    e. Vitamin D acts as a sleep “aid.” (18)
    f. Crucial for brain health, low levels of Vitamin D lead to anxiety, attention deficits, depression, cognitive decline, mood disorders, obsessive-compulsive tendencies, and schizophrenia and Alzheimer’s disease. (19)
    g. Vitamin D increases free testosterone concentrations by affecting the cholesterol side chain cleavage enzyme. This enzyme converts cholesterol into pregnenolone, the precursor of sex hormones, including testosterone. (20)
  5. Nucleotides:
    a. Nucleotides are essential molecules involved in cellular repair and regeneration. (21)
    b. Nucleotides form the building blocks of DNA. Adequate nucleotide availability is necessary for efficient DNA repair. (22)
    c. Involved in energy metabolism, nucleotides, specifically in ATP production, ensure optimal energy while combating age-related fatigue. (23)
    d. A key component in collagen synthesis, nucleotides supply tissue structural support and elasticity. Adequate nucleotide levels contribute to the maintenance of healthy, youthful-looking skin and tissue integrity. (24)
    e. A “must have” for proper immune function, nucleotides support the production and maturation of immune cells, our primary defense against invading pathogens. (25)
    f. Nucleotides participate in synthesizing signaling regulators cyclic adenosine monophosphate (cAMP) and guanosine monophosphate (cGMP), which regulate cellular processes. (26)
  6. Beta Cyclodextrin
    a. Obtained from starch and composed of seven glucose units in a ring-like structure, beta-cyclodextrin is used as an inclusion complex to enhance the absorption and bioavailability of other ingredients. (27)
    b. By forming complexes with various compounds, beta-cyclodextrin improves the solubility and stability of the components of a supplement or drug while ensuring efficient utilization and maximizing their benefits.
    c. Utilized in the food and fragrance industries, beta-cyclodextrin preserves sensitive flavors and aromas, preventing their degradation due to exposure to light, heat, or oxidation.
    d. On a global scale, beta-cyclodextrins form inclusion complexes with air pollutants and soil contaminants, aiding environmental cleanup efforts. (28)
  7. Fisetin
    a. Fisetin, a flavonoid in various fruits and vegetables, exhibits potent antioxidant and anti-inflammatory properties. (29)
    b. Oxidative stress (OS) disrupts macromolecules’ chemical integrity, increasing the risk of neurodegenerative diseases.
    c. Fisetin protects against age-related cognitive decline, improves memory, and promotes synaptic plasticity, essential for optimal brain function. (30)
    d. Fisetin plays a crucial role in improving focus, concentration, and mood. (31)
  8. Beta Glucan
    a. A polysaccharide found in yeast, oats, and mushrooms, beta-glucan modulates the immune system. (32)
    b. Beta-glucan activates immune cells, enhancing their ability to defend against pathogens and decreasing chronic inflammation. (33)
    c. Beta-glucans boost collagen for more youthful appearing skin, reduce the appearance of fine lines and wrinkles, improve skin elasticity and firmness, enhance skin hydration and moisture retention, and support a healthy, vibrant complexion. (34)
  9. Vitamin B1 as Benfotiamine:
    a. Vitamin B1, in the form of benfotiamine, supplies superior bioavailability to traditional vitamin B1.
    b. Benfotiamine protects nerve tissue against oxidative stress and the formation of advanced glycation end-products (AGEs). (35)
    c. AGEs are associated with accelerated aging and various age-related diseases. (36)
    d. Benfotiamine enhances cognitive function and mental clarity. (37)
    e. Benfotiamine supports healthy skin aging and appearance by promoting collagen production.
    f. Benfotamine reduces wrinkles and age spots. (38)
  10. Lutein/Zeaxanthin:
    a. Carotenoids that act as powerful antioxidants, lutein, and zeaxanthin, enhance visual acuity and protect against age-related macular degeneration (AMD) and cataracts. (39)
    b. Lutein and Zeaxanthin reduce oxidative stress throughout the body and support overall health and longevity. (40)
    c. Lutein and Zeaxanthin promote healthy skin by improving hydration while preventing the formation of fine lines and wrinkles. (41)
  11. Hyaluronic Acid:
    a. Hyaluronic acid is a naturally occurring substance in the skin, connective tissues, and joints.
    b. Hyaluronic acid is crucial in maintaining skin hydration for a plump, youthful appearance.
    c. Hyaluronic acid improves skin elasticity and firmness, enhances moisture retention, restores dry, dull-looking skin, and reduces “age” spots and uneven skin tone. (42)
    d. Hyaluronic acid contributes to joint lubrication, comfort, and flexibility. (43)

Teddy reiterated his pessimism about finding a simple supplement that embraces all of his ‘white-hot” must-have ingredients.

I quickly addressed his concern.

Au contraire,” Teddy, I texed back. “Au contraire. Your description of the ‘ideal’ anti-aging, anti-inflammatory, antioxidant supplements is right before me.”

Longevinex packagingAdvantage packageNot possible,” he answered.

“Not only possible,” I replied. “I’m holding it in my hands right now. Longevinex and Longevinex Advantage contain every ingredient you listed.”

  1. Trans-resveratrol: Antioxidant, anti-inflammatory.
  2. Quercetin: Antioxidant, immune system support.
  3. Rice bran IP6: Antioxidant, cholesterol and blood sugar lowering, anti-cancer agent.
  4. Vitamin D3: Bone health, immune support.
  5. Nucleotides: DNA and RNA building blocks.
  6. Beta cyclodextrin: Encapsulation, drug delivery system.
  7. Fisetin: Anti-oxidant, anti-aging properties.
  8. Beta Glucan: Immune system modulation
  9. Vitamin B1 as Benfotiamine: Nerve health, energy metabolism.
  10. Lutein/Zeaxanthin: Eye health, antioxidant protection.
  11. Hyaluronic acid: Skin hydration, joint health.


Longevinex and Longevinex Advantages’ combination of constituents allows us to simplify any anti-aging, anti-inflammatory, and antioxidant support regimen. This single-agent approach is cost-effective compared with multiple separate supplements. The ingredients are synergistic with one another for amplified results (1+ 1=5 rather than 2), and we can better effect a comprehensive regimen for overall well-being.


Single combination agents Longevinex and Longevinex Advantage pack the eleven essential ingredients necessary for a complete anti-aging, anti-inflammatory, and anti-oxidant regimen. Expected benefits include:

  1. Enhanced cellular function and longevity through the activation of longevity genes.
  2. Protection against oxidative stress and inflammation.
  3. Support of cardiovascular health.
  4. Improved cognitive function, memory, and brain health.
  5. The positive effect of the immune system and defense against pathogens.
  6. Prevention of glycation-related damage and preservation of nerve function.
  7. Support for eye health and reduced risk of age-related vision disorders.
  8. Support for skin hydration, elasticity, and joint flexibility.

I reminded Teddy that Longevinex and Longevinex Advantage are part of a comprehensive approach to overall well-being. A balanced diet, regular exercise, adequate sleep, stress management, and target supplementation are all essential for a healthy, maturing lifestyle.


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