by William Clearfield, D.O. for Longevinex


Step into the innovative world of Longevinex® – your ultimate destination for wellness and anti-aging solutions. Join us as we explore a wealth of self-help knowledge and high-powered products that surpass ordinary supplements.  (1)  

Behold Longevinex® and Longevinex Advantage™, our flagship supplements. These unique formula remedies are beacons of holistic health. Today, we delve into the synergistic effects of these two supplements, offering support for heart and cardiovascular health, circulation, improved energy levels, cognitive health, and macular degeneration. Join us as we unlock some of our favorite tips and tricks for living a longer, healthier life, reminiscent of the Fraggles from Fraggle Rock and their doozer sticks.


Our journey begins with Longevinex®, the flagship supplement. Meticulously formulated to bolster cardiovascular health, Longevinex’s “secret” ingredient, derived from Japanese knotweed, trans-resveratrol, is a highly purified and potent age-defying polyphenol. Japanese knotweed-derived trans-resveratrol ensures a standardized, concentrated product that maximizes resveratrol’s bioavailability and effectiveness.

Longevinex packaging

Unlike nearly all of the 350 other (cis) resveratrols on the market, Longevinex® trans-resveratrol epigenetically stimulates longevity and drives cellular respiration.  Trans-resveratrol (RSV) protects cells from oxidative stress, supports cardiovascular health, reduces inflammation, resists neoplastic cell changes, and enhances memory, cognition, and bone strength.  

Advanced medical literature reveals more than fifty functions and peer-reviewed studies on the healing powers of trans-resveratrol. (2-4)  

50 Ways Resveratrol Improves Health (2-4)

  1. Reduces inflammation.
  2. Improves cholesterol
  3. Increases insulin sensitivity
  4. Protects the heart 
  5. It is an anti-cancer agent
  6. Enhances memory and cognition
  7. Improves bone strength
  8. Increases your wind and endurance
  9. Helps you lose weight
  10.  Improves your skin.
  11. Protects against ultraviolet radiation
  12.  Protects against macular degeneration
  13. Improves liver function
  14. Lowers cholesterol
  15. Protects against atherosclerosis
  16. Protects the brain/decreases CVA risk
  17. Reduces the incidence of diabetes
  18. Enhances the immune system
  19. Protects against infections
  20. Improves respiratory function
  21. Reduces reactive oxidative stress,
  22. Improves sleep 
  23. Helps alleviate anxiety
  24. Helps alleviate depression
  25. Reduces joint pain. 
  26. Improves muscle strength
  27. Aids in erectile dysfunction
  28. Protects the brain from neurodegenerative diseases, Alzheimer’s, and Parkinson’s Disease
  29. Increases longevity
  30. Protects the gut.
  31. Protects against foodborne illnesses
  32. Reduces asthma
  33. Lessens autoimmune disease symptoms
  34. Protects the liver
  35. Protects the kidney
  36. Lessens menopause symptoms
  37. Improves fertility
  38. It can strengthen your teeth and gums
  39. It is an anti-viral agent
  40. Reduces arthritis
  41. Improves ADHD symptoms
  42. Improves your lung function
  43. Protects the skin against cancer
  44. Improves insulin resistance
  45. Reduces the risk of heart disease
  46. Reduces the risk of dementia
  47. Reduces the risk of obesity
  48. Balances estrogen
  49. Reduces chronic fatigue syndrome
  50. Reduces the risk of and improves the outcomes of migraine headaches

The following example illustrates resveratrol’s profound impact on cholesterol metabolism. 

Resveratrol Improves HDL (Good) Cholesterol and Reduces LDL (Bad Cholesterol) (5-6)

A study of middle-aged and elderly mice found a significant difference in cholesterol levels if treatment started early. (5-month-old mice are equivalent to ages 39-47 in human years.  7-month-old mice are equal to ages 56-69). 

HMG-Co synthase and reductase are the enzymes that control cholesterol synthesis. On average, resveratrol reduces total cholesterol by 7.65 mg/dL.

Another study concerning the cardioprotective properties of trans-resveratrol found an increase in nitric oxide (NO) and a decrease in lactate dehydrogenase levels, increasing blood flow to the heart and brain. (7)

RSV reduces the incidence and duration of ventricular tachycardia (VT) and ventricular fibrillation (VF), prevents damage to blood vessels, reduces low-density lipoprotein (LDL) cholesterol (the “bad” cholesterol), and prevents blood clots. (8)

For drinkers, resveratrol reduces the relative cardiovascular risk (RR) dose-dependently with red but not white wine consumption. A significant risk reduction (RR: 0.66, 95% CI 0.57-0.75) is associated with moderate (1-2 drinks or 150-300 mL/d) versus no wine consumption. (9)

The scope of Longevinex® extends far beyond just cardiovascular wellness. It stands as a pivotal component in the quest for longevity. Groundbreaking research reveals compelling evidence that resveratrol can emulate the effects of caloric restriction, a well-documented method for extending lifespan. (10)

In essence, Longevinex® is not just a supplement but a testament to the synergy of nature and scientific advancement.  By harnessing the power of resveratrol,  Longevinex® offers a dual promise – a more robust, healthier essence leading to a longer, more fulfilling life.

Longevinex Advantage™

Building on the foundation of Longevinex®, Longevinex®, Advantage™ takes the benefits to the next level. Designed with the same foundation and longevity benefits as Longevinex®,,

Advantage™ adds hyaluronic acid to thicken hair, produce smooth skin, lubricate joints, and cushion nerves, lutein/zeaxanthin to protect the eyes and skin from solar radiation aging, and Benfotiamine, a form of Vitamin B1, a known anti-aging nutrient. (11)

Advantage package


Longevinex provides powerhouse products, Longevinex®,, Longevinex®, Advantage™, T-Cell Zinc™, Garlinex™, and Garligest™, to improve wellness and longevity.

Trans-resveratrol derived from Japanese Knotweed in RP’s flagship supplement, Longevinex®,, performs at least 50 proven beneficial functions, including inflammation reduction, cholesterol-lowering, and improving insulin sensitivity.

Longevinex Advantage™ ups Longevinex’s game by adding hyaluronic acid to thicken hair, smooth skin, and lubricate joints, lutein/zeaxanthin to protect the eyes and skin from solar radiation aging, and Benfotiamine, an anti-aging nutrient. 

Longevinex is a master innovator in immune modulation.  In part 2 of “Embracing Holistic Health with Longevinex : A Journey Towards Longevity,” we will examine their cardiovascular and gastrointestinal modulating agents, Garlinex™ and Garligest™.  


William Clearfield, DO F.A.A.F.R.M., F.A.A.M.A., D.A.B.M.A.

Medical Health Contributor | Executive Director, American Osteopathic Society of Rheumatic Diseases American Osteopathic Society of Integrative Medicine


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